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  • Title: Antibody responses to norovirus genogroup GI.1 and GII.4 proteases in volunteers administered Norwalk virus.
    Author: Ajami NJ, Barry MA, Carrillo B, Muhaxhiri Z, Neill FH, Prasad BV, Opekun AR, Gilger MA, Graham DY, Atmar RL, Estes MK.
    Journal: Clin Vaccine Immunol; 2012 Dec; 19(12):1980-3. PubMed ID: 23035177.
    Abstract:
    An assay was developed to detect antibodies against two norovirus proteases among participants in a Norwalk virus (GI.1) challenge study. Prechallenge seroprevalence was lower against the protease from the homologous GI.1 virus than against protease from a heterologous GII.4 strain. Seroresponses were detected for 14 of 19 (74%) infected persons.
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