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  • Title: Elastography of soft materials and tissues by holographic imaging of surface acoustic waves.
    Author: Mohan KD, Oldenburg AL.
    Journal: Opt Express; 2012 Aug 13; 20(17):18887-97. PubMed ID: 23038528.
    Abstract:
    We use optical interferometry to capture coherent surface acoustic waves for elastographic imaging. An inverse method is employed to convert multi-frequency data into an elastic depth profile. Using this method, we image elastic properties over a 55 mm range with <5 mm resolution. For relevance to breast cancer detection, we employ a tissue phantom with a tumor-like inclusion. Holographic elastography is also shown to be well-behaved in ex vivo tissue, revealing the subsurface position of a bone. Because digital holography can assess waves over a wide surface area, this constitutes a flexible new platform for large volume and non-invasive elastography.
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