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  • Title: Pharmacogenetic determinant of the drug interaction between tacrolimus and omeprazole.
    Author: Zhao W, Fakhoury M, Maisin A, Baudouin V, Storme T, Deschênes G, Jacqz-Aigrain E.
    Journal: Ther Drug Monit; 2012 Dec; 34(6):739-41. PubMed ID: 23042259.
    Abstract:
    A 17-year-old adolescent with acute nephrotoxicity had CYP3A4-5, CYP2C19, and ABCB1 genotyping performed to understand a suspected drug interaction between tacrolimus and omeprazole. The determinant role of individual pharmacogenetic profile in the occurrence of tacrolimus nephrotoxicity is presented and discussed.
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