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  • Title: Near-infrared spectroscopy during exercise and recovery in children with juvenile dermatomyositis.
    Author: Habers GE, De Knikker R, Van Brussel M, Hulzebos E, Stegeman DF, Van Royen A, Takken T.
    Journal: Muscle Nerve; 2013 Jan; 47(1):108-15. PubMed ID: 23042630.
    Abstract:
    INTRODUCTION: We hypothesized that microvascular disturbances in muscle tissue play a role in the reduced exercise capacity in juvenile dermatomyositis (JDM). METHODS: Children with JDM, children with juvenile idiopathic arthritis (clinical controls), and healthy children performed a maximal incremental cycloergometric test from which normalized concentration changes in oxygenated hemoglobin (Δ[O2 Hb]) and total hemoglobin (Δ[tHb]) as well as the half-recovery times of both signals were determined from the vastus medialis and vastus lateralis muscles using near-infrared spectroscopy. RESULTS: Children with JDM had lower Δ[tHb] values in the vastus medialis at work rates of 25%, 50%, 75%, and 100% of maximal compared with healthy children; the increase in Δ[tHb] with increasing intensity seen in healthy children was absent in children with JDM. Other outcome measures did not differ by group. CONCLUSIONS: The results suggest that children with JDM may experience difficulties in increasing muscle blood volume with more strenuous exercise.
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