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  • Title: Preparation of 3,4,5-trisubstituted oxazolones by Pd-catalyzed coupling of N-alkynyl tert-butyloxycarbamates with aryl halides and related electrophiles.
    Author: Lu Z, Cui W, Xia S, Bai Y, Luo F, Zhu G.
    Journal: J Org Chem; 2012 Nov 02; 77(21):9871-7. PubMed ID: 23046091.
    Abstract:
    A novel palladium-catalyzed approach for the assembly of 3,4,5-trisubstituted oxazolones has been achieved by the coupling of N-alkynyl tert-butyloxycarbamates with aryl halides and related electrophiles, which involves an oxidative addition followed by oxypalladation/reductive elimination. The reaction provides a convenient access to diversely substituted oxazolones in satisfactory yields and shows good functional group compatibility.
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