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  • Title: [Research progress of cell dedifferentiation induced by reversine].
    Author: Hu X, Zhang X, Zhou Y, Yu Y, Xu H.
    Journal: Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2012 Sep; 26(9):1126-9. PubMed ID: 23057363.
    Abstract:
    OBJECTIVE: To review the research progress of different ways of stem cells generation and cells dedifferentiation induced by reversine. METHODS: The papers related to reversine inducing cells dedifferentiation and stem cells generation were reviewed. RESULTS: To obtain stem cells, there are always some disadvantages via somatic cell nuclear transfer or gene transfection. However reversine, a small molecule, can induce cells dedifferentiation which has unique advantage. But its mechanism is still unclear. CONCLUSION: The chemical approach for generation of induced pluripotent stem cells by reversine may take the place of other methods.
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