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  • Title: The impact of age on outcome of embryonal and alveolar rhabdomyosarcoma patients. A multicenter study.
    Author: Van Gaal JC, Van Der Graaf WT, Rikhof B, Van Hoesel QG, Teerenstra S, Suurmeijer AJ, Flucke UE, Loeffen JL, Sleijfer S, De Bont ES.
    Journal: Anticancer Res; 2012 Oct; 32(10):4485-97. PubMed ID: 23060577.
    Abstract:
    BACKGROUND: The prognosis of rhabdomyosarcoma (RMS) in children and adolescents has improved since the introduction of multi-agent chemotherapy. However, outcome data of adults with RMS are scarce. This multicenter retrospective study investigated the effect of age on outcome of RMS. PATIENTS AND METHODS: Data were collected from three Dutch University Medical Centers between 1977-2009. The effect of age and clinical prognostic factors on relapse-free and disease-specific survival (DSS) were analyzed. RESULTS: Age as a continuous variable predicted poor survival in multivariate analysis. Five-year DSS was highest for non-metastatic embryonal RMS, followed by non-metastatic alveolar RMS and was poor in metastatic disease. Higher age correlated with unfavorable histological subtype (alveolar RMS) and with metastatic disease at presentation in embryonal RMS. In non-metastatic embryonal RMS and in all alveolar RMS, higher age was an adverse prognostic factor of outcome. CONCLUSION: This study indicates that age is a negative predictor of survival in patients with embryonal and alveolar RMS.
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