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  • Title: Molecular mechanisms of fMLP-induced superoxide generation and degranulation in mouse neutrophils.
    Author: Kanaho Y, Sato T, Hongu T, Funakoshi Y.
    Journal: Adv Biol Regul; 2013 Jan; 53(1):128-34. PubMed ID: 23062771.
    Abstract:
    In this manuscript, involvement of PLD in fMLP-induced superoxide generation and degranulation were re-investigated using PLD(-/-) neutrophils, and the molecular mechanisms of these neutrophil functions were examined. Neither PLD1 nor PLD2 is involved in these fMLP-induced neutrophil functions. The results obtained in this study provide evidence that cPKC plays an important role in fMLP-induced superoxide generation. On the other hand, Ca(2+)-dependent signaling pathway and cPKC seem to be involved in degranulation.
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