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  • Title: Migraine with aura associated with unilateral cortical increase in vascular permeability.
    Author: Rotstein DL, Aviv RI, Murray BJ.
    Journal: Cephalalgia; 2012 Dec; 32(16):1216-9. PubMed ID: 23064237.
    Abstract:
    BACKGROUND: Few studies to date have captured perfusion and vascular permeability changes during a migraineur's aura. This may be important information to the clinician in the context of the differential diagnosis of migraine with aura versus acute stroke. SUMMARY: We report a case in which magnetic resonance perfusion during a migraine aura showed unilateral hypoperfusion differentially affecting gray and white matter and was associated with a hemispheric increase in permeability. CONCLUSIONS: Imaging in this case suggests that migraine aura is associated with oligemia below the threshold for infarction. Increased vascular permeability may be a critical mechanism contributing to perfusion changes observed in migraine with aura.
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