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  • Title: Improving drug adherence using fixed combinations caused beneficial treatment outcomes and decreased health-care costs in patients with hypertension.
    Author: Kumagai N, Onishi K, Hoshino K, Nakamori S, Kitai T, Yazu T, Oota M, Ueda Y, Hiraoka N, Okamoto S, Yamada T, Dohi K, Nakamura M, Ito M.
    Journal: Clin Exp Hypertens; 2013; 35(5):355-60. PubMed ID: 23072348.
    Abstract:
    We enrolled 196 patients with hypertension who were already being treated with free-drug combinations of angiotensin-II receptor blocker (ARB) and amlodipine. The free-drug combinations of ARB and amlodipine were replaced with the same dose of the fixed-dose combinations. The average home blood pressure (BP) in all patients receiving fixed-dose combinations was significantly lower than those receiving free-drug combinations (131 ± 10/75 ± 8 vs. 136 ± 11/77 ± 9 mm Hg, P < .01) accompanied with increasing drug adherence. After lowering BP by fixed-dose combinations, the costs for medications decreased by 31% over the 3 months.
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