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  • Title: Effects of lipoic acid in an experimentally induced hypertensive and diabetic rat model.
    Author: Mıcılı SC, Ergur BU, Ozoğul C, Sarıoğlu S, Bağrıyanık HA, Tuğyan K, Pekcetin C, Sonmez U, Tekmen I, Erbil G, Akdoğan GG, Ozyurt D, Buldan Z.
    Journal: Clin Exp Hypertens; 2013; 35(5):373-81. PubMed ID: 23072377.
    Abstract:
    In this study, experimental diabetes and nephrectomy have been applied separately and together in order to investigate the possible therapeutic effects of lipoic acid (LA) on hypertensive and diabetic rat kidneys. Wistar rats were divided into eight groups: control, diabetes mellitus (DM), 5/6 nephrectomy, DM + 5/6 nephrectomy, LA administration, DM + LA treated, 5/6 nephrectomy + LA treated, and DM + 5/6 nephrectomy + LA-treated groups, respectively. Renal damage was evaluated histomorphometrically, ultrastructurally, and biochemically. Our findings supported that diabetes and hypertension together increased the rate of renal injury, and LA had therapeutic effects on hypertensive and diabetic rat kidneys.
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