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  • Title: Intraductal tubular neoplasms of the bile ducts.
    Author: Katabi N, Torres J, Klimstra DS.
    Journal: Am J Surg Pathol; 2012 Nov; 36(11):1647-55. PubMed ID: 23073323.
    Abstract:
    Although most tumors of the bile ducts are predominantly invasive, some have an exophytic pattern within the bile ducts; these intraductal papillary neoplasms usually have well-formed papillae at the microscopic level. In this study, however, we describe a novel type of intraductal neoplasm of the bile ducts with a predominantly tubular growth pattern and other distinctive features. Ten cases of biliary intraductal neoplasms with a predominantly tubular architecture were identified in the files of the Pathology Department at Memorial Sloan-Kettering Cancer Center from 1983 to 2006. For each of these cases we studied the clinical presentation, histologic and immunohistochemical features (9 cases only), and the clinical follow-up of the patients. Three male and 7 female patients (38 to 78 y) presented with obstructive jaundice or abdominal pain. Eight of the patients underwent a partial hepatectomy; 2 underwent a laparoscopic bile duct excision, followed by a pancreatoduodenectomy in one of them. The tumors range in size from 0.6 to 8.0 cm. The intraductal portions of the tumors (8 intrahepatic, 1 extrahepatic hilar, 1 common bile duct) were densely cellular and composed of back-to-back tubular glands and solid sheets with minimal papillary architecture. The cells were cuboidal to columnar with mild to moderate cytologic atypia. Foci of necrosis were present in the intraductal component in 6 cases. An extraductal invasive carcinoma component was present in 7 cases, composing <25% of the tumor in 4 cases, and >75% in 1 case. It was observed by immunohistochemical analysis that the tumor cells expressed CK19, CA19-9, MUC1, and MUC6 in most cases and that SMAD4 expression was retained. MUC2, MUC5AC, HepPar1, synaptophysin, chromogranin, p53, and CA125 were negative in all cases and most were negative for CEA-M and B72.3. Four patients were free of tumor recurrence after 7 to 85 months (average, 27 mo). Four patients with an invasive carcinoma component suffered metastases, 1 after local intraductal recurrence. However, the occurrence of metastasis in 3 of these patients was quite late (average, 52 mo). Intraductal tubular neoplasm of the bile ducts is a biliary intraductal neoplasm with a distinctive histologic pattern resembling the recently described intraductal tubulopapillary neoplasm of the pancreas. Immunohistochemical features are similar to those of other pancreatobiliary-type carcinomas. However, this tumor may be hard to recognize as intraductal because of its complex architecture. When the tumor is entirely intraductal, the outcome appears to be favorable, but metastases can occur when invasive carcinoma is present, even after many years.
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