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  • Title: [Influence of interleukin-13 on bioelectrical activity of rat atrial cardiomyocytes in normal and stretch conditions].
    Author: Mitrokhin VM, Makarenko EIu, Abramochkin DV, Kamkin AG.
    Journal: Ross Fiziol Zh Im I M Sechenova; 2012 Jul; 98(7):827-35. PubMed ID: 23074830.
    Abstract:
    We studied the effect of anti-inflammatory ininterleukin-13 (IL-13; 50 ng/ml) on bioelectrical activity of rat atrial cardiomyocytes under control conditions and on the background of stretch by means of microelectrode technique. IL-13 did not lead to alterations of the resting membrane potential and action potential amplitude during 35 minutes. However APD25, APD50, APD90 in 50% of cases significantly decreased, while in other 50% of cases it increased. In case when IL-13 decreased APD cellular stretch by 1.7 mN caused an increase in APD frequency by 120% and caused decrease in APD25, APD50, APD90, which happened on the background of modest cellular depolarization in the range of 5 mV. When IL-13 increased APD, tissue stretching just by 0.8 mN caused depression of the frequency by 10% and increase in APD25, APD50, APD90. This happened on the background of small cellular depolarization.
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