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  • Title: Activity of alkanediol alkanoates against pathogenic plant fungi Rhizoctonia solani and Sclerotium rolfsii.
    Author: Shukla P, Walia S, Ahluwalia V, Parmar BS, Nair MG.
    Journal: Nat Prod Commun; 2012 Sep; 7(9):1219-22. PubMed ID: 23074913.
    Abstract:
    Thirty known dialkanoates of ethylene, propylene and diethylene glycols were synthesized by reacting the glycols with acyl chlorides and their structures confirmed by IR, NMR and mass spectral analyses. They exhibited significant antifungal activity against two phytopathogenic fungi Rhizoctonia solani Kuehn and Sclerotium rolfsii Sacc in a dose dependent manner. Propylene glycol dipentanoate was the most active against R. solani. followed by diethylene glycol dibutanoate and ethylene glycol dibutanoate. Against S. rolfsii ethylene glycol diheptanoate was found to be most active followed by diethylene glycol diisobutanoate As compared to the standard reference benomyl (EC50 5.16 microg/mL), the potential alkanediol dialkanoates showed EC50 in the range of 33 - 60 microg/mL.
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