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  • Title: [Cyclooxigenase-1 gene polymorphism and aspirin resistance].
    Author: Bondar' TN, Kravchenko NA.
    Journal: Tsitol Genet; 2012; 46(4):66-72. PubMed ID: 23074965.
    Abstract:
    The literature data concerning structure of cyclo-oxigenase-1--the key enzyme in prostaglandin biosynthesis and the main target of anti-platelet therapy with the use of acetylsalicilic acid are presented in the review. The data on cyclooxigenase-1 gene polymorphism, distribution of the revealed variants in various populations and their possible correlation with biochemical and functional aspirin resistance are presented.
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