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  • Title: Effect of vitamin E on 2-deoxy-D-glucose uptake in human fibroblast cultures.
    Author: Couturier M, Lemonnier F, Conti M, Feneant-Thibault M, Lemonnier A.
    Journal: In Vitro Cell Dev Biol; 1990 Jan; 26(1):29-32. PubMed ID: 2307637.
    Abstract:
    2-Deoxy-D-glucose (2-DOG) uptake was tested in human fibroblast cultures in the presence and absence of vitamin E. Addition of 10 micrograms/ml vitamin E to the culture medium significantly reduced this uptake for 2-DOG concentrations of 0.005 to 10 mmol/liter (P less than or equal to 0.01). The decrease of 2-DOG uptake was inversely proportional to the rise in 2-DOG concentration (P less than or equal to 0.01). The presence of vitamin E reduced by 71% the average cellular level of lipid peroxides (expressed as thiobarbituric acid reactive substances) and caused a small but significant decrease in the cholesterol concentration (P less than or equal to 0.01). These last results might explain the decrease in 2-DOG uptake observed in the presence of vitamin E.
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