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  • Title: Label-free imaging of cerebral β-amyloidosis with extended-focus optical coherence microscopy.
    Author: Bolmont T, Bouwens A, Pache C, Dimitrov M, Berclaz C, Villiger M, Wegenast-Braun BM, Lasser T, Fraering PC.
    Journal: J Neurosci; 2012 Oct 17; 32(42):14548-56. PubMed ID: 23077040.
    Abstract:
    We demonstrate label-free imaging of cerebral β-amyloidosis ex vivo and in a living mouse model of Alzheimer's disease using extended-focus Fourier domain optical coherence microscopy (xfOCM). xfOCM provides 3D, high-resolution images of individual β-amyloid plaques in the brain parenchyma and vasculature and requires no staining of the alzheimeric sample under investigation. xfOCM also opens the possibility to perform minimally invasive studies of β-amyloid pathology in vivo, without the use of labeling methods, which potentially confound experimental findings.
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