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  • Title: Safety and efficacy of buprenorphine for analgesia in laboratory mice and rats.
    Author: Guarnieri M, Brayton C, DeTolla L, Forbes-McBean N, Sarabia-Estrada R, Zadnik P.
    Journal: Lab Anim (NY); 2012 Nov; 41(11):337-43. PubMed ID: 23079917.
    Abstract:
    Buprenorphine is a long-acting opiate with a high therapeutic index. The authors review the pharmacology, toxicity, analgesic effects and delivery of buprenorphine for use in laboratory mice and rats. Buprenorphine-based analgesic therapy has a substantial record of safety, and there is growing evidence of its effectiveness for treating post-operative pain. Nonetheless, more research is needed to determine optimal delivery systems and analgesic regimens for pain therapy in laboratory animals.
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