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  • Title: Treatment of hepatitis C in patients infected with human immunodeficiency virus in the direct-acting antiviral era.
    Author: Soriano V, Labarga P, Vispo E, Fernández-Montero JV, Barreiro P.
    Journal: Infect Dis Clin North Am; 2012 Dec; 26(4):931-48. PubMed ID: 23083825.
    Abstract:
    Chronic hepatitis C is a leading cause of clinical complications and mortality in individuals infected with human immunodeficiency virus (HIV). Approval for the first direct-acting antiviral (DAA) against the hepatitis C virus (HCV) has been eagerly awaited for treating patients coinfected with HIV/HCV. The use of first-generation HCV protease inhibitors is challenged by complicated dosing schedules, frequent serious toxicities, unwanted drug interactions, drug resistance, and high cost. First-generation DAAs will eventually be replaced by more potent, well-tolerated, and convenient agents. HIV/HCV co-infection will become restricted to individuals without proper access to health care.
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