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  • Title: Effects of carbogen on cochlear blood flow and hearing function following acute acoustic trauma in guinea pigs.
    Author: Zhao J, Sun J, Liu Y.
    Journal: Arch Med Res; 2012 Oct; 43(7):530-5. PubMed ID: 23085262.
    Abstract:
    BACKGROUND AND AIMS: Disturbances of microcirculation and hemorheological changes in the inner ear are the results of noise-induced hearing loss (NIHL). Both the disturbances of microcirculation and hemorheological changes are the etiologies of NIHL development, but they are also the results. Although previous reports that inhalation of high concentration of CO(2) may increase cochlear blood flow (CoBF), the effects of carbogen on the cochlear microcirculation and NIHL remain unclear. METHODS: Changes induced by noise, carbogen and pure oxygen within the cochlear lateral wall microvasculature and in hearing thresholds were observed in guinea pigs using intravital microscopy and the auditory brainstem response. At the same time, arterial oxygen saturation and morphologic changes of cochlear hair cells were observed. RESULTS: Carbogen inhalation increased vessel diameters and blood flow velocities. Hearing thresholds elevation in the carbogen group was smaller than those in the control and oxygen group (p <0.05). Carbogen inhalation produced a trend toward less threshold shift after noise exposure, which reached statistical significance after day 3 (p <0.01). Respiratory acidosis was not found in our study. The segmented basal membranes of Corti in three groups indicated that no losses or discorders of hair cells were found. CONCLUSIONS: Carbogen inhalation can preserve hearing in animal models after acute acoustic trauma.
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