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  • Title: Efficient synthesis and first regioselective C-3 direct arylation of imidazo[1,2-b]pyrazoles.
    Author: Grosse S, Pillard C, Massip S, Léger JM, Jarry C, Bourg S, Bernard P, Guillaumet G.
    Journal: Chemistry; 2012 Nov 19; 18(47):14943-7. PubMed ID: 23086664.
    Abstract:
    Highly regioselective: An efficient synthesis of the imidazo[1,2-b]pyrazole core has been developed, and the first regioselective palladium-catalyzed direct arylation of the C-3 position is described (see scheme). Good to excellent yields were obtained for a wide range of aryl partners with electron-rich and electron-poor substituents. This methodology allows rapid access to a large variety of imidazo[1,2-b]pyrazole products and could open the way to the design of new biologically active compounds.
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