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  • Title: Trimethoprim-sulfamethoxazole-induced Steven Johnson syndrome in an HIV-infected patient.
    Author: Taqi SA, Zaki SA, Nilofer AR, Sami LB.
    Journal: Indian J Pharmacol; 2012; 44(4):533-5. PubMed ID: 23087524.
    Abstract:
    Trimethoprim-sulfamethoxazole (TMP/SMX) is a widely prescribed antimicrobial for the management of several uncomplicated infections. It is commonly used for the treatment and prophylaxis of Pneumocystis jirovecii pneumonia (PCP) in the HIV-infected population. The adverse reaction to TMP/SMX is more frequent and severe in HIV-infected patients as compared to the general population. Here, we report a case of Stevens-Johnson syndrome (SJS) secondary to TMP/SMX. The patient had a generalized cutaneous reaction with involvement of the eyes, oral cavity, and genitals. He had elevated hepatic alanine aminotransferase and aspartate aminotransferase enzyme. TMP/SMX therapy was stopped and supportive treatment was started. His condition improved after eight days of stopping TMP/SMX therapy.
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