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  • Title: HIV-associated multicentric Castleman's disease.
    Author: Naime Fde F, Fakhouri F, Martins CS, Couto WJ.
    Journal: Rare Tumors; 2012 Jun 26; 4(3):e40. PubMed ID: 23087796.
    Abstract:
    Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder. It is found with higher frequency in patients with HIV infection, with systemic symptoms and poor prognosis. We present the case of a 32-year old man with HIV disease, Kaposi's sarcoma, lymphadenopathy, fever and hemolytic anemia. A diagnosis of Castleman's disease is confirmed through biopsy and treatment is often based only on published case reports. Systemic treatments for MCD have included chemotherapy, anti-herpes virus, highly active antiretroviral therapy and, more recently, monoclonal antibodies against both IL6 and CD20.
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