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  • Title: Highly regioselective nitrile oxide dipolar cycloadditions with ortho-nitrophenyl alkynes.
    Author: McIntosh ML, Naffziger MR, Ashburn BO, Zakharov LN, Carter RG.
    Journal: Org Biomol Chem; 2012 Dec 14; 10(46):9204-13. PubMed ID: 23090640.
    Abstract:
    The dipolar cycloadditions of ortho-nitrophenyl alkynes with aryl nitrile oxides has been demonstrated. A range of substituents are tolerated on the alkyne. These reactions proceed with excellent levels of regioselectivity. Subsequent functionalization of the isoxazole scaffold has been demonstrated.
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