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  • Title: [Preventive antibiotics in emergency cesarean section. A prospective comparison of benzylpenicillin and ampicillin plus cloxacillin].
    Author: Fredriksson A, Thomassen P.
    Journal: Tidsskr Nor Laegeforen; 1990 Jan 30; 110(3):348-50. PubMed ID: 2309177.
    Abstract:
    Emergency cesarean section, especially when performed more than ten hours after rupture of the membranes, involves a high risk of postoperative infection. Different antibiotic regimens have been shown to reduce these infections substantially. In this prospective study a combination of ampicilling (2 g) plus kloxacillin (2 g) given as a single-dose infusion directly after division of the cord reduced the post-operative infection rate to 13% in a group of high-risk emergency cesarean section cases. Benzylpenicillin only (2 g) was less efficient. No side-effects were observed, and this prophylaxis may have certain advantages over cephalosporins, especially with respect to enterococcus-induced endometritis.
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