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  • Title: Uvaridacols E-H, highly oxygenated antiausterity agents from Uvaria dac.
    Author: Awale S, Ueda JY, Athikomkulchai S, Dibwe DF, Abdelhamed S, Yokoyama S, Saiki I, Miyatake R.
    Journal: J Nat Prod; 2012 Nov 26; 75(11):1999-2002. PubMed ID: 23092429.
    Abstract:
    Chemical investigation of the stems of Uvaria dac yielded four new highly oxygenated cyclohexene derivatives named uvaridacols E-H (1-4). Their structures were established through NMR and circular dichroism spectroscopic analysis. Uvaridacols E (1), F (2), and H (4) displayed weak preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions in a concentration-dependent manner, without causing toxicity in normal nutrient-rich conditions.
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