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Title: Design of highly potent HIV fusion inhibitors based on artificial peptide sequences. Author: Shi W, Cai L, Lu L, Wang C, Wang K, Xu L, Zhang S, Han H, Jiang X, Zheng B, Jiang S, Liu K. Journal: Chem Commun (Camb); 2012 Dec 07; 48(94):11579-81. PubMed ID: 23093045. Abstract: Specific interactions were introduced between an artificial heptad repeat peptide template and HIV-1 gp41 for fusion inhibitor design, using a structure based rational design strategy. The designed peptides are nonhomologous with naturally occurring peptide and protein sequences, specifically interact with HIV-1 gp41, and show strong anti-HIV activity.[Abstract] [Full Text] [Related] [New Search]