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  • Title: Rapid differentiation of subarachnoid hemorrhage from traumatic lumbar puncture using the D-dimer assay.
    Author: Lang DT, Berberian LB, Lee S, Ault M.
    Journal: Am J Clin Pathol; 1990 Mar; 93(3):403-5. PubMed ID: 2309662.
    Abstract:
    The D-dimer assay of 40 cerebral spinal fluid (CSF) samples accurately differentiated subarachnoid hemorrhage (SAH) from traumatic lumbar puncture. The D-dimer assay was positive in all six patients with subarachnoid hemorrhage. Negative D-dimer values were obtained in control groups of 14 patients with hemorrhagic CSF secondary to traumatic lumbar puncture (LP) and in 20 patients with normal CSF. The D-dimer assay proved to be a better test than xanthochromia or the decline in erythrocyte count in sequentially collected tubes in differentiating subarachnoid hemorrhage from traumatic LP.
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