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  • Title: A meta-analysis characterizing the dose-response relationships for three oral nitrogen-containing bisphosphonates in postmenopausal women.
    Author: Yates J.
    Journal: Osteoporos Int; 2013 Jan; 24(1):253-62. PubMed ID: 23100120.
    Abstract:
    UNLABELLED: A meta-analysis of spine BMD dose-response relationships for alendronate, risedronate, and ibandronate was performed. Data from all three oral bisphosphonates conform to a log-linear relationship between dose and change in spine BMD relative to placebo at 1 year, with an incremental gain of about 1 % for each doubling of dose. INTRODUCTION: Animal data suggesting differences in potency and differences in approved oral dosage strengths for alendronate, risedronate, and ibandronate in the treatment of osteoporosis raise questions about their dose-response relationships and relative potencies in humans. METHODS: A meta-analysis of dose-response relationships for spine BMD increases for these three bisphosphonates was performed using data from 21 placebo-controlled trials that collectively included over 13,000 patients on active treatment and over 8,000 on placebo. RESULTS: For alendronate over the range of 1 to 20 mg/day, there was a strong log-linear relationship between dose and the increase in spine BMD relative to placebo at 1 year (R (2) = 0.994 using sample-weighted means). For each doubling in alendronate dose, there was an incremental gain of about 1 % in spine BMD. On the same scale, risedronate and ibandronate are approximately equipotent to alendronate on a weight-for-weight basis. The increases in BMD efficacy with each doubling of dose are parallel for all three nitrogen-containing bisphosphonates (NCBPs). CONCLUSIONS: All three NCBPs are approximately equipotent and exhibit a log-linear relationship between dose and the increase in spine BMD. Differences in efficacy between the available oral bisphosphonate regimens appear to be a function of dose rather than inherent differences in therapeutic potential.
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