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  • Title: [Intensity of lipid peroxidation and antioxidant protection system indices in the course of a 3-day "dry" immersion experiment].
    Author: Zhuravleva OA, Morukov BV, Markin AA, Vostrikova LV, Zabolotskaia IV, Kuzitchkin DS.
    Journal: Fiziol Cheloveka; 2012; 38(5):120-3. PubMed ID: 23101250.
    Abstract:
    In the course of a 3-day "dry" immersion experiment involving participation of five male test volunteers aged 25 to 40, in the blood serum of participants were determined the content of LPO (lipid peroxidation) products, namely diene conjugates, malon dialdehyde, shiffbases, as well as the values of the antioxidant protection system (AOP) indices - the concentration of tocopherol as the main lipid antioxidant and the level of general antioxidant activity. During the immersion action no deviations of indices under study from the background values were revealed, with the exception of a certain increase in tocopherol concentration within two hours after experiment beginning. At the restoring period after two hours upon immersion completion a reliable increase of lipid peroxidation products, particularly diene conjugates in participants' blood serum was made evident. At this, the tocopherol content was significantly below the background values. It is therefore concluded that the test participants' adaptation to the simulated weightlessness conditions shows no pronounced stress component, whereas bringing back to normal vital functions after exposure to immersion occurs with significantly pronounced stress reaction development, as demonstrated by considerable growth of LPO processes against the background of AOP system functional activity reducing.
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