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  • Title: Intravoxel incoherent motion imaging of the kidney: alterations in diffusion and perfusion in patients with renal dysfunction.
    Author: Ichikawa S, Motosugi U, Ichikawa T, Sano K, Morisaka H, Araki T.
    Journal: Magn Reson Imaging; 2013 Apr; 31(3):414-7. PubMed ID: 23102943.
    Abstract:
    PURPOSE: To investigate the relationship between estimated glomerular filtration rate (eGFR) and parameters calculated using intravoxel incoherent motion (IVIM) imaging of the kidneys. MATERIALS AND METHODS: We studied 365 patients, divided into 4 groups based on eGFR levels (mL/min/1.73m(2)): group 1, eGFR≥80(n=80); group 2, eGFR 60-80 (n=156); group 3, eGFR 30-60 (n=114); and group 4 ,eGFR<30 (n=15). IVIM imaging was used to acquire diffusion-weighted images at 12 b values. The diffusion coefficient of pure molecular diffusion (D), the diffusion coefficient of microcirculation or perfusion (D*), and perfusion fraction (f) were compared among the groups using group 1 as control. RESULTS: In the renal cortex, D* values were significantly lower in groups 2, 3, and 4 than in group 1. The D value of renal cortex was significantly low in only group 3. In the renal medulla, the D* and D values were significantly lower only in groups 2 and 3, respectively. CONCLUSION: As renal dysfunction progresses, renal perfusion might be reduced earlier and affected more than molecular diffusion in the renal cortex. These changes are effectively detected by IVIM MR imaging.
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