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  • Title: New concepts in the generation and functions of IgA.
    Author: Pabst O.
    Journal: Nat Rev Immunol; 2012 Dec; 12(12):821-32. PubMed ID: 23103985.
    Abstract:
    The intestinal mucosa contains the largest population of antibody-secreting plasma cells in the body, and in humans several grams of secretory immunoglobulin A (SIgA) are released into the intestine each day. In the gut lumen, SIgA serves as a first-line barrier that protects the epithelium from pathogens and toxins. Recently, next-generation sequencing has revolutionized our understanding of the nature of the intestinal microbiota and has also shed new light on the important roles of SIgA in the regulation of host-commensal homeostasis. Here, I discuss pathways of IgA induction in the context of SIgA specificity and function.
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