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  • Title: Transport of glutathione across the mitochondrial membranes.
    Author: Kurosawa K, Hayashi N, Sato N, Kamada T, Tagawa K.
    Journal: Biochem Biophys Res Commun; 1990 Feb 28; 167(1):367-72. PubMed ID: 2310399.
    Abstract:
    Transport of glutathione (GSH) into mitochondria was observed when mitochondria in state 4 respiration were incubated with high concentrations of GSH. This transport was suppressed by antimycin A or dicyclohexyl-carbodiimide, or in state 3 respiration. Upon dissipation of the proton gradient by a proton ionophore, mitochondrial GSH was released into the medium. GSH moved freely across the proton-permeated mitochondrial membrane, its movement depending only on the GSH gradient across the inner membrane. These results indicate that there is a transport system for GSH in the mitochondrial membrane, and that a proton gradient is necessary to maintain GSH in the matrix, and to transport GSH into mitochondria.
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