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  • Title: Optimal treatment for asymptomatic neurosyphilis.
    Author: Tsai HC, Sy CL, Lee SS, Wann SR, Chen YS.
    Journal: Int J STD AIDS; 2012 Oct; 23(10):756-7. PubMed ID: 23104753.
    Abstract:
    In the pre-penicillin era, patients with asymptomatic neurosyphilis (ANS) were more likely to develop long-term neurological sequelae than those patients with normal cerebrospinal fluid (CSF). Although benzathine penicillin G cannot achieve treponemicidal levels in the CSF, decreased rates of neurological complications of syphilis and non-treponemal titre serological responses are usually observed after treatment with this antibiotic. We here a homosexual man with ANS successfully treated with benzathine penicillin G. This case suggests that reconsideration on the necessity of a lumbar puncture in HIV-infected patients with ANS is warranted.
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