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  • Title: New 14-membered cyclopeptide alkaloids from Zizyphus oxyphylla Edgew.
    Author: Kaleem WA, Nisar M, Qayum M, Zia-Ul-Haq M, Adhikari A, De Feo V.
    Journal: Int J Mol Sci; 2012; 13(9):11520-11529. PubMed ID: 23109868.
    Abstract:
    Two new 14-membered cyclopeptide alkaloids, Oxyphylline B (4) and Oxyphylline C (5), along with three known 13-membered cyclopeptide alkaloids, were isolated from stem and roots of Zizyphus oxyphylla Edgew. The compounds were tested for antibacterial activity. Oxyphylline B (4) showed comparatively better antibacterial activities against Escherichia coli (MIC, 5 μg/mL) than other compounds. This compound also exhibited weak antimicrobial activities against Staphylococcus aureus (MIC, 25 μg/mL), Pseudomonas aeruginosa (MIC, 50 μg/mL) and Salmonella typhi (MIC, 50 μg/mL).
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