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  • Title: Evidence that hippocampal-parahippocampal dysfunction is related to genetic risk for schizophrenia.
    Author: Di Giorgio A, Gelao B, Caforio G, Romano R, Andriola I, D'Ambrosio E, Papazacharias A, Elifani F, Bianco LL, Taurisano P, Fazio L, Popolizio T, Blasi G, Bertolino A.
    Journal: Psychol Med; 2013 Aug; 43(8):1661-71. PubMed ID: 23111173.
    Abstract:
    BACKGROUND: Abnormalities in hippocampal-parahippocampal (H-PH) function are prominent features of schizophrenia and have been associated with deficits in episodic memory. However, it remains unclear whether these abnormalities represent a phenotype related to genetic risk for schizophrenia or whether they are related to disease state. METHOD: We investigated H-PH-mediated behavior and physiology, using blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI), during episodic memory in a sample of patients with schizophrenia, clinically unaffected siblings and healthy subjects. RESULTS: Patients with schizophrenia and unaffected siblings displayed abnormalities in episodic memory performance. During an fMRI memory encoding task, both patients and siblings demonstrated a similar pattern of reduced H-PH engagement compared with healthy subjects. CONCLUSIONS: Our findings suggest that the pathophysiological mechanism underlying the inability of patients with schizophrenia to properly engage the H-PH during episodic memory is related to genetic risk for the disorder. Therefore, H-PH dysfunction can be assumed as a schizophrenia susceptibility-related phenotype.
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