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  • Title: Highly enantio- and diastereoselective generation of two quaternary centers in spirocyclopropanation of oxindole derivatives.
    Author: Noole A, Sucman NS, Kabeshov MA, Kanger T, Macaev FZ, Malkov AV.
    Journal: Chemistry; 2012 Nov 19; 18(47):14929-33. PubMed ID: 23112107.
    Abstract:
    Spirocyclopropanes: Only one out of eight possible stereoisomers was obtained in the asymmetric cascade cyclopropanation of alkylidene oxindoles with ethyl 2-chloroacetoacetate. Improved catalyst design ensured that spirocyclopropyl oxindoles featuring two quaternary centers were synthesized in high yield and high enantio- and diastereoselectivity (see scheme).
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