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  • Title: Reticulohistiocytoma cutis--review of 15 cases and an association with systemic vasculitis in two cases.
    Author: Oliver GF, Umbert I, Winkelmann RK, Muller SA.
    Journal: Clin Exp Dermatol; 1990 Jan; 15(1):1-6. PubMed ID: 2311271.
    Abstract:
    We reviewed 15 cases of reticulohistiocytoma cutis (RHC). Three cases were of solitary lesions. Four cases were associated with a destructive arthritis but no other systemic features. One additional patient had a destructive arthritis and lesions of reticulohistiocytoma in synovium, larynx, and mucosa. Three patients had associated xanthelasma. Two cases were associated with internal malignancy (metastatic malignant melanoma, adenocarcinoma of the bowel). Two cases were sequentially associated with systemic vasculitis (Wegener's granulomatosis, periarteritis nodosa). This occurrence of systemic vasculitis in RHC patients is unique. RHC may have variable cutaneous and systemic manifestations and associations with malignancy and immunoinflammatory diseases, including vasculitis.
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