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  • Title: Potentiation of hemostimulating effects of erythropoietin with pegylated hyaluronate-endo-β-N-acetylhexosaminidase.
    Author: Dygai AM, Zyuz'kov GN, Zhdanov VV, Udut EV, Gurto RV, Miroshnichenko LA, Simanina EV, Khrichkova TIu, Stavrova LA, Chaikovsky AV, Artamonov AV, Bekarev AA, Madonov PG, Minakova MIu, Markova TS.
    Journal: Bull Exp Biol Med; 2012 Sep; 153(5):684-8. PubMed ID: 23113258.
    Abstract:
    Pegylated hyaluronate-endo-β-N-acetylhexosaminidase considerably potentiates the hemostimulating effects of erythropoietin due to intensification of proliferation and differentiation of erythroid precursors against the background of enhanced secretion of hemopoietins by nonadherent hemopoiesis-inducing environment cells and elevation of serum erythropoietin concentration. The use of the enzyme allows 10-fold reduction of the maximum effective erythropoietin dose.
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