These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of triterpene derivatives on the total hepatocyte count in the liver of rats with toxic hepatitis.
    Author: Semenov DE, Zhukova NA, Bessergeneva EP, Sorokina IV, Baev DS, Glukhov BM, Nepomnyaschikh GI, Tolstikova TG.
    Journal: Bull Exp Biol Med; 2012 Oct; 153(6):858-61. PubMed ID: 23113303.
    Abstract:
    We studied hepatoprotective activity of betulonic acid and its alaninamide on the model of combined CCl(4)- and ethanol-induced toxic liver damage in rats. The test substances, especially betulonic acid alaninamide, considerably reduced the elevated biochemical parameters in animals with toxic liver damage. Betulonic acid alaninamide also stimulated reparative processes in the liver (activated hepatocyte proliferation). Heptral (reference drug) produced no appreciable effects on the reparative processes. Our findings suggest that betulin derivatives exhibit pronounced protective properties.
    [Abstract] [Full Text] [Related] [New Search]