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  • Title: [Detection and clinical significance of Th1/Th2 cytokines in patients with idiopathic thrombocytopenic purpura].
    Author: Guo XH, Zhao F, Shi W, Ma XM, Xu Q, Patiguli AB, Halida YS.
    Journal: Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2012 Nov; 28(11):1185-7. PubMed ID: 23127411.
    Abstract:
    AIM: To observe Th1 (IL-2 and IFN-γ) and Th2 (IL-4, IL-10) cytokine changes in patients with idiopathic thrombocytopenic purpura (ITP) and explore the correlation between ITP development and Th1/Th2. METHODS: A total of 30 patients with ITP and 26 healthy volunteers were enrolled in this study. Serum levels of IL-2, IFN-γ, IL-4, and IL-10 were detected by enzyme-linked immunosorbent assay (ELISA) before and after treatment. RESULTS: The serum levels of IFN-γ and IL-2 in patients with ITP before the glucocorticoid treatment were significantly higher than those after the treatment and in the control groups (P<0.05), while the serum levels of IL-4 and IL-10 in patients with ITP before treatment were significantly lower than those after the treatment and in the control group (P<0.05). CONCLUSION: Th1/Th2 imbalance plays a prominent role in the development of ITP, and glucocorticoid treatment helps to restore the Th1/Th2 in the patients with ITP.
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