These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Enzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres.
    Author: Popat A, Ross BP, Liu J, Jambhrunkar S, Kleitz F, Qiao SZ.
    Journal: Angew Chem Int Ed Engl; 2012 Dec 07; 51(50):12486-9. PubMed ID: 23129230.
    Abstract:
    I want to break free: Mesoporous silica nanoparticles are functionalized with sulfasalazine (SZ; see scheme), a prodrug of 5-aminosalicylic acid (5-ASA) and sulfapyridine, to generate enzyme-responsive nanocarriers. In the presence of the colon-specific enzyme azo-reductase (orange), 5-ASA and sulfapyridine are efficiently released.
    [Abstract] [Full Text] [Related] [New Search]