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  • Title: Association between KCNE1 (G38S) genetic polymorphism and non-valvular atrial fibrillation in an Uygur population.
    Author: Haijun M, Xiaohui Z, Ting M, Renner W, Abulizi P, Baopeng T.
    Journal: Wien Klin Wochenschr; 2012 Nov; 124(21-22):737-41. PubMed ID: 23129484.
    Abstract:
    BACKGROUND: The relationship between KCNE1 G38S genetic polymorphism and non-valvular atrial fibrillation is different among different populations. The study explored the KCNE1 G38S to understand if the KCNE1 G38S is associated with the Uygur atrial fibrillation patients. METHODS: KCNE1 G38S genetic polymorphism was determined between 237 non-valvular atrial fibrillation cases and 237 control subjects using PCR-RFLP. RESULTS: In univariate analyses, there was a statistical difference in genotype distribution between the patients and controls, and a significant difference in allele frequency of KCNE1 G38S was observed between the two groups (62.6 vs 52.7 %, p = 0.003). In multivariate analyses, the KCNE1 38G variant was independently associated with a significant predisposing effect on AF after adjusting for related risk factors, and the odds ratio for patients was 1.634 (95 % CI: 1.192-2.240, p = 0.002). CONCLUSION: The KCNE1 38G is a risk factor for incident AF in an Uygur population. The KCNE1 G38S might have different impact on AF in different ethnicities.
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