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  • Title: Safety of urate-lowering therapies: managing the risks to gain the benefits.
    Author: Keenan RT.
    Journal: Rheum Dis Clin North Am; 2012 Nov; 38(4):663-80. PubMed ID: 23137576.
    Abstract:
    Gout is a metabolic disorder of purine metabolism and uric acid elimination. Over time, acute gout can develop into a chronic, disabling arthropathy, often associated with multiple comorbidities. Gout patients have often been undertreated, partly because of the clinician's perceived risks of a therapy outweighing its potential benefits. The approval of new therapies to treat hyperuricemia in gout has led to a new understanding of gout management and medication safety regarding new and old therapies. This review focuses on potential safety issues of currently available urate-lowering therapies and outlines strategies to minimize risks so their benefits can be reached.
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