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  • Title: Effects of cromakalim (BRL 34915) and pinacidil on normal and hypertrophied rat detrusor in vitro.
    Author: Malmgren A, Andersson KE, Andersson PO, Fovaeus M, Sjögren C.
    Journal: J Urol; 1990 Apr; 143(4):828-34. PubMed ID: 2313820.
    Abstract:
    Normal and hypertrophied rat detrusor were investigated in vitro with regard to effects of the K(+)-channel openers pinacidil and cromakalim. Both drugs abolished spontaneous contractile activity and induced a relaxation of normal and hypertrophied detrusor preparations. In both types of preparation, contractions elicited by K+, carbachol or electrical field stimulation were depressed in the presence of the K(+)-channel openers. Responses induced by K+ or electrical stimulation were more reduced in the hypertrophied than in the normal detrusor. Both K(+)-channel openers increased the efflux of 86Rb+ in a concentration-dependent way and this increase was similar in normal and hypertrophied detrusor. If applicable to man, this data suggest that K(+)-channel openers may be effective in the treatment of bladder instability secondary to outflow obstruction.
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