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  • Title: Development of a dual functional luminescent sensor for zinc ion based on a peptidic architecture.
    Author: Hirayama T, Taki M, Akaoka K, Yamamoto Y.
    Journal: Bioorg Med Chem Lett; 2012 Dec 15; 22(24):7410-3. PubMed ID: 23140887.
    Abstract:
    A synthetic peptide bearing a lanthanide complex, TbOTZ exhibits a decrease of chromophore fluorescence and a concomitant luminescence enhancement due to sensitized Tb(3+) upon Zn(2+) binding. Thus, TbOTZ can be a valuable tool for ratiometric sensing of Zn(2+) as well as for time-resolved fluorescence detection with a single molecule.
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