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  • Title: Evaluation of core-shell particle columns for ion-pair reversed-phase liquid chromatography analysis of oligonucleotides.
    Author: Biba M, Welch CJ, Foley JP, Mao B, Vazquez E, Arvary RA.
    Journal: J Pharm Biomed Anal; 2013 Jan; 72():25-32. PubMed ID: 23146223.
    Abstract:
    An investigation into the use of core-shell particle columns for separation of short (∼21 base pairs) RNA oligonucleotides by ion-pair reversed-phase liquid chromatography (IP-RPLC) showed improved resolution for a number of test analytes relative to conventional (fully-porous) reversed-phase columns. The best resolutions were obtained using columns packed with smaller sub-2μm core-shell particles.
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