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  • Title: An epidemic of Pneumocystis jiroveci pneumonia in a renal transplantation center: role of T-cell lymphopenia.
    Author: Brunot V, Pernin V, Chartier C, Garrigue V, Vetromile F, Szwarc I, Delmas S, Portalès P, Basset D, Mourad G.
    Journal: Transplant Proc; 2012 Nov; 44(9):2818-20. PubMed ID: 23146531.
    Abstract:
    Although only 2 cases of Pneumocystis jiroveci pneumonia were observed in our center between 2004 and 2009, we diagnosed 9 cases in 2010. Each patient had been in contact in the hospital with at least 1 other patient suffering P jiroveci pneumonia. Genotyping of P jiroveci pneumonia strains demonstrates a total homogeneity of the DNA sequences in the 7 patients already analyzed. CD4+ lymphocyte count was significantly lower at M3 in P jiroveci pneumonia patients than in controls. Our clinical and molecular data confirm that interhuman transmission of P jiroveci is possible, particularly to lymphopenic transplant recipients.
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