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  • Title: Maternal fecundity and asthma among offspring-is the risk programmed preconceptionally? Retrospective observational study.
    Author: Harju M, Keski-Nisula L, Raatikainen K, Pekkanen J, Heinonen S.
    Journal: Fertil Steril; 2013 Mar 01; 99(3):761-767.e1. PubMed ID: 23148921.
    Abstract:
    OBJECTIVE: To evaluate the association between maternal fecundity factors and time to pregnancy and risk of asthma in offspring. DESIGN: Retrospective observational hospital-based birth cohort study. SETTING: A university-based obstetrics and gynecology department. PATIENT(S): A total of 40,914 women, who delivered between 1989 and 2007, were linked with the register for asthma reimbursement (n = 2,577) for their offspring. Fecundity factors were recorded during pregnancy. Logistic regression analyses were used. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Asthma among offspring. RESULT(S): The risk of asthma was significantly increased if the mother had any infertility problems (adjusted odds ratio [adjusted OR] 1.39, 95% confidence interval [CI] 1.19-1.63), medical infertility treatment (aOR 1.43, 95% CI 1.13-1.80), or any infertility treatment (aOR 1.50, 95% CI 1.26-1.79). The risk of asthma among offspring was also higher among mothers who had more than two miscarriages (aOR 1.25, 95% CI 1.04-1.51) and time to pregnancy over 3 months (aOR 1.25, 95% CI 1.07-1.45). CONCLUSION(S): These findings suggest that maternal subfertility exposes offspring to an increased risk of asthma. CLINICAL TRIAL REGISTRATION NUMBER: The study is registered in Kuopio University Hospital register (TUTKI): ID 5302448.
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