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  • Title: Reduction of helical content by insertion of a disulfide bond leads to an antimicrobial peptide with decreased hemolytic activity.
    Author: Hwang H, Hyun S, Kim Y, Yu J.
    Journal: ChemMedChem; 2013 Jan; 8(1):59-62. PubMed ID: 23150226.
    Abstract:
    CAPs off to the S-S bond: Application of a strategy involving the introduction of intramolecular disulfide bonds to amphipathic cationic antimicrobial peptides (CAPs) led to decreased α-helicity and hydrophobicity. The mutant peptides were observed to have significantly increased (250-fold) minimum hemolytic concentrations while maintaining MIC values against E. coli, affording more therapeutically selective CAPs.
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